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As someone who lost 140 pounds on Zepbound, I have my first experience with skin fold issues

Tirzepatide may not be recommended for individuals who: Have a personal or family history of medullary thyroid carcinoma (MTC) Have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Are pregnant, planning to become pregnant, or breastfeeding Have a history of pancreatitis Have severe gastrointestinal disease (such as severe gastroparesis) Have experienced a serious allergic reaction to tirzepatide or its components Have certain uncontrolled endocrine or metabolic conditions Are using other medications that may conflict with GLP-1/GIP therapy Individuals with type 1 diabetes or a history of diabetic ketoacidosis are generally not candidates for tirzepatide

Lifestyle measures can support hormonal balance during this transition

Swapping refined grains for whole grains can also increase your intake of fibre, an important nutrient linked to boosting GLP-1 levels and improving metabolic health

During the menopausal transition, up to 70% of women gain weight

& Kostev, K