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In chemico reactivity studies discussed earlier use a large molar excess of the chemical to model the nucleophile and show rapid depletion of the model nucleophile and/or formation of adducts with the electrophilic molecule

Clinical studies have used doses around 1,200mg per day, but even lower doses may offer benefit, especially when combined with other antioxidants like ALA.51 The one major drawback of Nerve Defend is its low B12 content