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High doses may lead to the K-hole phenomenon, characterized by extreme dissociation without loss of consciousness (Malhotra et al., 1996)

Acetylated glutathione not only increases the stability and lipophilicity of Glutathione but also allows it to sneak past the cellular defenses and enter cells more efficiently (Cacciatore et al., 2010)

Furthermore, hyper-dopaminergic states induced by amphetamine can induce mitochondrial damage through the HIF1 pathway [107], suggesting another potential pathway by which NAC might serve a neuroprotective function against THC-induced cortical pathology

GLP-1s help improve metabolic health by influencing several key processes: Blood Sugar Regulation: By enhancing insulin secretion and reducing glucagon release, GLP-1s help maintain stable blood sugar levels, reducing the spikes and crashes that contribute to metabolic dysfunction

Relevant clinical trials should assess outcomes such as sleep-onset latency, total sleep time, wakefulness after sleep onset, sleep efficiency, daytime functioning and patient-reported symptoms